Osteoporosis is a condition characterized by weakened bones, making them fragile and more prone to fractures.
Frequently Asked Questions
How is osteoporosis different from osteomalacia?
Osteoporosis is loss of bone density, bones become porous and brittle but the remaining bone is still normal in composition. Osteomalacia is defective mineralisation, bones are soft because they lack calcium and phosphorus deposition, usually from vitamin D deficiency. Different cause, different treatment.
Can you have both osteoporosis and osteomalacia?
Yes, and it's actually common in older adults. Chronic vitamin D deficiency can cause osteomalacia on top of age-related osteoporosis. That's why a workup for suspected osteoporosis usually includes a 25-OH-D vitamin D level, you treat both if both are present.
How is osteomalacia diagnosed?
Blood tests for low vitamin D, low calcium, low phosphate, and raised alkaline phosphatase and PTH. X-rays may show Looser's zones (pseudofractures). Bone biopsy is rarely needed. Unlike osteoporosis, DEXA scan alone doesn't diagnose osteomalacia.
What is the treatment for osteomalacia?
High-dose vitamin D (usually 60,000 IU weekly for 8 weeks then maintenance) plus calcium supplementation. Pain and weakness usually improve within 4–6 weeks. For malabsorption cases, injectable vitamin D may be needed. Follow-up 25-OH-D at 3 months to confirm response.
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